Study of sesquiterpene lactones and coumarin derivatives of Centaurea salicifolia M.Bieb. Ex Willd.

Summary

The article for the first time provides information on sesquiterpene lactones and coumarin derivatives accumulating in the aerial parts of the species Centaureae salisifolia (cornflower) growing in Azerbaijan. The use of substances obtained from C. salicifolia in folk and scientific medicine in the treatment of a number of diseases, in particular for activating the central nervous system, as pain relievers, wound healing, diuretics, for bronchial asthma, headache, against malignant tumors, photosensitizing, as coronary vasodilators is great interest to study its chemical composition. In this regard, the aim of the research was to study the qualitative composition of sesquiterpene lactones and coumarins accumulating in the aerial parts of C. salisifolia. The material for the study was the aerial part of the C. salisifolia plant collected in the budding phase in the village of Gechresh, Guba region. The method of column chromatography (h = 14 cm, d = 2.5 cm) filled with Al2 O3 was used to obtain sesquiterpene lactones and coumarins in the individual state from the sum of extractives; to determine the individuality of sesquiterpene lactones and coumarins, the method of preparative chromatography on silufol UV-254 plates was used, IR- and nuclear magnetic resonance (NMR) methods were used to identify individual sesquiterpene lactones and coumarins. The resulting substances were identified as α-santonine, cnicin and scopoletin. 

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